Control of Myocardial Contraction: The Sensitivity of Cardiac Actomyosin to Calcium Ion
- 27 May 1966
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 152 (3726), 1242-1243
- https://doi.org/10.1126/science.152.3726.1242
Abstract
The control by calcium ion of the adenosine triphosphatase activity of cardiac actomyosin is similar to that of white skeletal actomyosin. This finding indicates that the slower contraction and relaxation of heart muscle do not reflect different levels to which free calcium ion concentration around the myofibrils must be adjusted during contraction and relaxation and suggests a mechanism whereby myocardial contractility may be regulated.This publication has 14 references indexed in Scilit:
- Purification and Properties of a Tropomyosin-containing Protein Fraction That Sensitizes Reconstituted Actomyosin to Calcium-binding AgentsJournal of Biological Chemistry, 1966
- Calcium Exchange in Dog Ventricular Muscle: Relation to Frequency of Contraction and Maintenance of ContractilityCirculation Research, 1965
- On the Mechanism of the Relaxing Effect of Fragmented Sarcoplasmic ReticulumThe Journal of general physiology, 1963
- ON THE STRUCTURAL CONTINUITIES OF THE TRANSVERSE TUBULAR SYSTEM OF RABBIT AND HUMAN MYOCARDIAL CELLSThe Journal of cell biology, 1963
- The Binding of Calcium to Actomyosin Systems in Relation to Their Biological ActivityJournal of Biological Chemistry, 1963
- ADENOSINE TRIPHOSPHATE-LINKED CONCENTRATION OF CALCIUM IONS IN A PARTICULATE FRACTION OF RABBIT MUSCLEThe Journal of cell biology, 1962
- THE FINE STRUCTURE OF SHEEP MYOCARDIAL CELLS; SARCOLEMMAL INVAGINATIONS AND THE TRANSVERSE TUBULAR SYSTEMThe Journal of cell biology, 1962
- The Sarcoplasmic Reticulum of Skeletal and Cardiac MuscleCirculation, 1961
- STUDIES ON THE ENDOPLASMIC RETICULUMThe Journal of cell biology, 1957
- A MICROCOLORIMETRIC METHOD FOR THE DETERMINATION OF INORGANIC PHOSPHORUSJournal of Biological Chemistry, 1953