Atorvastatin prevents Plasmodium falciparum cytoadherence and endothelial damage
Open Access
- 28 February 2011
- journal article
- Published by Springer Nature in Malaria Journal
- Vol. 10 (1), 52
- https://doi.org/10.1186/1475-2875-10-52
Abstract
The adhesion of Plasmodium falciparum parasitized red blood cell (PRBC) to human endothelial cells (EC) induces inflammatory processes, coagulation cascades, oxidative stress and apoptosis. These pathological processes are suspected to be responsible for the blood-brain-barrier and other organs' endothelial dysfunctions observed in fatal cases of malaria. Atorvastatin, a drug that belongs to the lowering cholesterol molecule family of statins, has been shown to ameliorate endothelial functions and is widely used in patients with cardiovascular disorders.Keywords
This publication has 51 references indexed in Scilit:
- Atorvastatin as a Potential Antimalarial Drug: In Vitro Synergy in Combinational Therapy with DihydroartemisininAntimicrobial Agents and Chemotherapy, 2010
- The murine cerebral malaria phenomenonTrends in Parasitology, 2009
- Plasmodium falciparum–infected erythrocytes induce NF-κB regulated inflammatory pathways in human cerebral endotheliumBlood, 2009
- Atorvastatin Is a Promising Partner for Antimalarial Drugs in Treatment of Plasmodium falciparum MalariaAntimicrobial Agents and Chemotherapy, 2009
- Statins Alone Are Ineffective in Cerebral Malaria but Potentiate ArtesunateAntimicrobial Agents and Chemotherapy, 2008
- Simvastatin Treatment Shows No Effect on the Incidence of Cerebral Malaria or Parasitemia during Experimental MalariaAntimicrobial Agents and Chemotherapy, 2008
- Plasmodium falciparumIntercellular Adhesion Molecule–1–Based Cytoadherence‐Related Signaling in Human Endothelial CellsThe Journal of Infectious Diseases, 2007
- Atorvastatin Is 10-Fold More Active In Vitro than Other Statins against Plasmodium falciparumAntimicrobial Agents and Chemotherapy, 2007
- The global distribution of clinical episodes of Plasmodium falciparum malariaNature, 2005
- Regulation of the mevalonate pathwayNature, 1990