Further Properties of Isoglutamine-oxytocin; Inhibition of Pressor Activity of Vasopressin.

Abstract

The isoglutamine isomer of oxytocin, which differs from oxytocin by substitution of an isoglutamine residue for the glutamine residue in the hormone, has been found to inhibit significantly the pressor activity of administered vasopressin in the anesthetized rat. Molecular weight, solubility, and analytical data suggest that acetic acid is lost when the polypeptide acetate is rigorously dried. Isoglutamine-oxytocin forms a crystalline flavianate salt.