Muscle morphology in infantile protein malnutrition
Open Access
- 1 November 1962
- journal article
- research article
- Published by BMJ in Journal of Clinical Pathology
- Vol. 15 (6), 511-521
- https://doi.org/10.1136/jcp.15.6.511
Abstract
A study was made of the sartorius muscle in Jamaican infants dying of protein malnutrition. Total counts were made of muscle fibres and sub-sarcolemmal nuclei in transverse section and compared with controls. A striking pathology is found in severe cases. The muscle fibre is reduced to a size comparable with that of the foetus. Although there is a greatly increased concentration of cells, there is also degeneration and actual loss of fibres and of sub-sarcolemmal nuclei. The proportion of the area occupied by muscle bundles may be halved, and there is a marked relative increase in interstitial collagen. These changes profoundly affect the interpretation of the results of biochemical analysis.This publication has 22 references indexed in Scilit:
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