INACTIVATION OF HL‐A ANTIGENS IN VITRO BY ACTION OF ANTIBIOTICS
- 1 February 1976
- journal article
- Published by Wiley in International Journal of Immunogenetics
- Vol. 3 (1), 29-33
- https://doi.org/10.1111/j.1744-313x.1976.tb00553.x
Abstract
The effect of antibiotics on lymphocyte HL-A antigens in vitro is of variable character. All antibiotics under examination suppressed the absorption capacity of HL-A antigens after 2 hr of lymphocyte treatment at 37°C. Ceporin and Kanamytrex inhibited even the cytotoxic reactivity of H1-A antigens after 15–30 min of lymphocyte treatment. Chloramphenicol, aureomycin, streptomycin and oleandomycin, on the contrary, increased the specific cytotoxic reactivity of HL-A antigens after 15–30 min, after 1 hr they were ineffective for HL-A antigens, and after two or more hours they produced polyreactivity. Penicillin and erythromycin produced polyreactivity after only 15–30 min. The results show that for the follow-up of the drug effect on HL-A antigens the absorption test rather than the cytotoxicity test is of importance. The suppressed absorption capacity of HL-A antigens caused by the action of antibiotics proves their inactivation effect on the lymphocytes. The possibility of an analogous effect of antibiotics on lymphocyte HL-A antigens, even after administration to patients, is discussed.Keywords
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