Vancomycin Resistance in Enterococci Due to Synthesis of Precursors Terminating in d -Alanyl- d -Serine

Abstract

Resistance to glycopeptides was not reported for approximately 30 years after the introduction of vancomycin into clinical practice, due partly to limited use of the antibiotic until the mid-1970s. The lengthy period was also due to the difficulties experienced by bacteria in developing mechanisms