Antiparkinsonian efficacy of a novel transdermal delivery system for (+)-PHNO in MPTP-treated squirrel monkeys
- 1 March 1989
- journal article
- research article
- Published by Wolters Kluwer Health in Neurology
- Vol. 39 (3), 329
- https://doi.org/10.1212/wnl.39.3.329
Abstract
We examined the ability of the antiparkinsonian agent (+)-4-propyl-9-hydroxynaphthoxazine (PHNO) to enter the systemic circulation in therapeutic concentrations after continuous transdermal absorption in squirrel monkeys rendered parkinsonian by MPTP. Direct subcutaneous administration of (+)-PHNO in the dose range of 2.5 to 20 μg/kg restored locomotor activity to levels seen in normal monkeys for approximately 1 hour. Application of transdermal patches capable of delivering, into an infinite sink, an estimated 2.6 μg/cm2/h of (+ )-PHNO over a skin surface area of 4.78 to 19.12 cm2 also restored locomotor activity to the normal range during a 24-hour period. We suggest the use of transdermal application of PHNO as a novel drug delivery system for the improved management of Parkinson's disease.This publication has 10 references indexed in Scilit:
- Long-term motor stimulant effects of (+)-4-propyl-9-hydroxynapthoxazine (PHNO), a dopamine D-2 receptor agonist: interactions with a dopamine D-1 receptor antagonist and agonistEuropean Journal of Pharmacology, 1988
- SUBCUTANEOUS APOMORPHINE IN PARKINSONIAN ON-OFF OSCILLATIONSThe Lancet, 1988
- Motor fluctuations in Parkinson's disease: Pathogenetic and therapeutic studiesAnnals of Neurology, 1987
- Variability and functional recovery in the N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine model of parkinsonism in monkeysNeuroscience, 1986
- Levodopa pharmacokinetics and pharmacodynamics in fluctuating parkinsonian patientsNeurology, 1986
- LISURIDE INFUSION PUMP: A DEVICE FOR THE TREATMENT OF MOTOR FLUCTUATIONS IN PARKINSON'S DISEASEThe Lancet, 1986
- (+)-4-PROPYL-9-HYDROXYNAPHTHOXAZINE (PHNO), A NEW DOPAMINOMIMETIC, IN TREATMENT OF PARKINSONISMThe Lancet, 1985
- Simultaneous monitoring of dopamine release in rat frontal cortex, nucleus accumbens and striatum: Effect of drugs, circadian changes and correlations with motor activityNeuroscience, 1985
- Synthesis of 4-substituted 2H-naphth[1,2-b]-1,4-oxazines, a new class of dopamine agonistsJournal of Medicinal Chemistry, 1984
- PHARMACOLOGIC PROFILE OF A NOVEL POTENT DIRECT-ACTING DOPAMINE AGONIST, "(+)-4-PROPYL-9-HYDROXYNAPHTHOXAZINE [(+)-PHNO]1984