Monoclonal anti-Fc receptor IgG blocks antibody enhancement of viral replication in macrophages
- 1 January 1981
- journal article
- research article
- Published by Springer Nature in Nature
- Vol. 289 (5794), 189-191
- https://doi.org/10.1038/289189a0
Abstract
West Nile virus (WNV) replication in the P388 D1 macrophage cell line provides a reproducible model system for studying ADE [antibody-dependent enhancement] of viral replication. Mouse macrophages have 2 FcR[Fc receptor]FcRI, which is trypsin-sensitive and binds IgG2a, and FcRII, which is trypsin-resistant and binds IgG2b and IgG1 complexes. The FcR was purified using rat anti-mouse FcRmonoclonal antibody which blocks FcRII. Anti-FcR IgG and its Fab fragment block ADE of virus replication by anti-WNV monoclonal antibodies.This publication has 10 references indexed in Scilit:
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