Channels, pumps, and exchangers in the gill and kidney of freshwater fishes: Their role in ionic and acid‐base regulation

Abstract

In freshwater fishes, the gill and kidney are intricately involved in ionic and acid‐base regulation owing to the presence of numerous ion channels, pumps, or exchangers. This review summarizes recent developments in branchial and renal ion transport physiology and presents several models that integrate epithelial ion and acid‐base movements in freshwater fishes. At the gill, three cell types are potentially involved in ionic uptake: pavement cells, mitochondria‐rich (MR) PNA⁺ cells, and MR PNA⁻ cells. The transfer of acidic or basic equivalents between the fish and its environment is accomplished largely by the gill and is appropriately regulated to correct acid‐base imbalances. The kidney, while less important than the gill in overall acid or base excretion, has an essential role in regulating systemic acid‐base balance by controlling HCO₃⁻ reabsorption from the filtrate. J. Exp. Zool. 300A:53–62, 2003.