PASSAGE OF I131-ALBUMIN + I125-GAMMA GLOBULIN INTO SMALL INTESTINE OF PIG

Abstract

Metabolism of I131 -albumin and I125-gamma globulin was examined simultaneously in 5 pigs (22-30 kg bodyweight). Total daily catabolism of albumin and gamma globulin was 12-23%/day and 10-13%/day, rsp. The excretion of the 2 proteins into the small intestine was studied in Thiry-Vella type loops, situated at different levels of the small intestine. Con- siderable amounts of protein-bound radio-activity could be detected in the succus entericus. Perfusions with isotonic Mg SO4 solution, normal saline and 10% Mg SO4 solution were followed by increased excretion of both proteins. The increase was very considerable, even when isotonic fluids were used. The excretion of the 2 proteins was of the same order of magnitude. Quantitative aspects are discussed, with special reference to the difficulties derived from the fact that little is known or secretory variations along the intestine and on the role played by the passage of digesta in the excretion of proteins.