Production of cytotoxic factor for oligodendrocytes by stimulated astrocytes.
Open Access
- 15 October 1987
- journal article
- research article
- Published by The American Association of Immunologists in The Journal of Immunology
- Vol. 139 (8), 2593-2597
- https://doi.org/10.4049/jimmunol.139.8.2593
Abstract
Stimulation of rat astrocytes in vitro by calcium ionophore A23187 and/or lipopolysaccharide results in the generation of a cytotoxic factor that is functionally similar to the previously described macrophage-derived cytotoxic factor, tumor necrosis factor. Like the macrophage product, the astrocyte cytotoxic factor kills murine L 929 cell targets. In addition, it kills rat oligodendrocytes, the myelin-producing cells of the central nervous system. Human recombinant tumor necrosis factor also has cytotoxic activity directed against rat oligodendrocytes.This publication has 14 references indexed in Scilit:
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