Neonatal Aplastic Anaemia and Fanconi's Anaemia

Abstract

Two cases, a mother and her daughter, are described. The mother had a congenitally dislocated hip and during childhood developed aplastic anemia from which she went into remission. The daughter had severe hemolytic disease at birth and died of marrow failure at 12 weeks of age. It is suggested that the mother''s illness is a forme fruste of Fanconi''s syndrome and that the baby''s marrow failure was the result of placental transfer of antibodies that were present in the mother before her blood transfusions (one of which sensitized her to D) or else were associated with the anti-D and persisted to cause the infant''s death.