Partial Purification and Properties of Tropine Dehydrogenase from Root Cultures ofDatura stramonium

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Abstract
From sterile root cultures of Datura stramonium, an NADP(H)-specific tropine dehydrogenase has been isolated and characterized. The enzyme catalyzes the reversible and stereospecific oxidation of tropine and related tropane-3α-ols to the corresponding ketone. Isomeric pseudotropine (tropane-3β-ol) is neither accepted as substrate nor produced in the reverse reaction. It is assumed that this dehydrogenase is involved in the biosynthesis of tropane alkaloids.