High expression ofN-acetylglucosaminyltransferase V in favorable neuroblastomas: Involvement of its effect on apoptosis
- 5 January 2006
- journal article
- Published by Wiley in FEBS Letters
- Vol. 580 (2), 627-632
- https://doi.org/10.1016/j.febslet.2005.12.089
Abstract
Neuroblastoma (NBL), derived from the sympathetic precursor cells, is one of the most common pediatric solid tumors. The expression of N-acetylglucosaminyltransferase V and IX (GnT-V and GnT-IX) mRNA in 126 primary NBLs were quantitatively analyzed and higher expression levels of GnT-V were found to be associated with favorable stages (1, 2 and 4s). Conversely, the downregulation of GnT-V expression by small interfering RNA resulted in a decrease in the susceptibility to cell apoptosis induced by retinoic acid in NBL cells accompanied by morphological change. These results suggest that GnT-V is associated with prognosis by modulating the sensitivity of NBLs to apoptosisKeywords
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