REDUCTION OF PLASMA TRIIODOTHYRONINE (T3) INDUCED BY PROPRANOLOL
- 1 June 1977
- journal article
- research article
- Published by Wiley in Clinical Endocrinology
- Vol. 6 (6), 405-410
- https://doi.org/10.1111/j.1365-2265.1977.tb03322.x
Abstract
The effect of propranolol on plasma triiodothyronine (T3), thyroxine (T4) and T3 uptake by Sephadex G-25 (RT3U%) was studied in 14 thyrotoxic patients and 8 normal volunteers. Propranolol (40 mg) as a single oral dose significantly reduced total serum T3 which began 60 min after administration. No significant changes were observed in T4 and RT3U% values. Plasma T3 levels remained suppressed during a 5 days course of treatment with propranolol. Propranolol probably has a direct effect on peripheral metabolism of T3 rather than on thyroid hormone secretion.This publication has 15 references indexed in Scilit:
- Effect of propranolol on various aspects of thyroid function in the ratMetabolism, 1974
- INFLUENCE OF PROPRANOLOL ON SERUM THYROXINE IN THE RATJournal of Endocrinology, 1972
- Triiodothyronine Turnover in Euthyroid SubjectsJournal of Clinical Endocrinology & Metabolism, 1971
- The extrathyroidal conversion rate of thyroxine to triiodothyronine in normal manJCI Insight, 1971
- EFFECT OF PROPRANOLOL ON SERUM-THYROXINEThe Lancet, 1970
- New Tactics for Hyperthyroidism: Sympathetic BlockadeAnnals of Internal Medicine, 1970
- CONTROLLED TRIAL OF PROPRANOLOL IN THYROTOXICOSISThe Lancet, 1969
- Treatment of Thyrotoxic Storm with Intravenous Administration of PropranololAnnals of Internal Medicine, 1969
- Total and Free Triiodothyronine in Human Serum*JCI Insight, 1967
- The Hemodynamic and Metabolic Interrelationships in the Activity of Epinephrine, Norepinephrine and the Thyroid HormonesCirculation, 1956