Increased Mortality in the Siblings and Offspring of Pi Type MS and MZ Men from Saskatchewan
- 1 January 1982
- journal article
- research article
- Published by S. Karger AG in Human Heredity
- Vol. 32 (3), 185-188
- https://doi.org/10.1159/000153288
Abstract
.alpha.1-Antitrypsin phenotypes were determined in 1395 male Saskatchewan grain buyers. These included 1254 type M, 80 MS, 35 MZ and 26 which were untyped or other rare phenotypes. Siblings and offspring of the MS men had a significantly greater number of deaths (P < 0.01). Offspring of MZ men also had an increased number of deaths. These appeared to occur in all age groups except in those 2-17 yr of age. This finding raises questions about the role of both the S and Z alleles.This publication has 5 references indexed in Scilit:
- Association between psoriasis and the alpha 1-antitrypsin deficiency gene ZActa Dermato-Venereologica, 1980
- Alpha_1-Antitrypsin Deficiency and Pancreatic FibrosisAnnals of Internal Medicine, 1976
- CLINICAL, EPIDEMIOLOGIC, AND PULMONARY-FUNCTION STUDIES IN ALPHA-1-ANTITRYPSIN-DEFICIENT SUBJECTS OF PI Z-TYPEPublished by Elsevier ,1976
- MEMBRANOPROLIFERATIVE GLOMERULONEPHRITIS IN CHILDHOOD CIRRHOSIS ASSOCIATED WITH ALPHA1-ANTITRYPSIN DEFICIENCY1976
- The Electrophoretic α;1-Globulin Pattern of Serum in α;1-Antitrypsin DeficiencyScandinavian Journal of Clinical and Laboratory Investigation, 1963