Morphological changes in Plasmodium cynomolgi following proguanil, sulphadiazine, and mepacrine therapy

Abstract

P cynomolgi stages in which the chromatin had begun to divide have their regular cycle modified by proguanil and sulphadiazine. These changes end in complete degeneration of the organisms except in resistant strains, in which degeneration is arrested before complete disintegration occurs. Other stages in the life cycle of the parasite were not visibly altered. After treatment with mepacrine the changes are mainly cytoplasmic, being particularly marked in the ring and ameboid trophozoite stages.