Isoproterenol in Comparison to WR-2721 as a Chemoradioprotector of the Rat Parotid Gland

Abstract

A comparison was made of the radioprotective abilities of the chemoradioprotector WR-2721, an amino-thiol, and the beta-sympathomimetic secretogogue isoproterenol on the rat parotid gland. Using the dose-response curve of WR-2721 for gland weights as a basis for comparison, isoproterenol was found to offer significant and equal protection during both the acute (DMF, 2.5) and the chronic (DMF, 2.3) periods.