Muscular dystrophy in six young girls

Abstract

Clinical and genetic studies were made on progressive muscular dystrophy in 6 young girls. No chromosome abnormality was observed in these patients. The pedigree of 1 case implied a sex-linked recessive trait, and clinical features were identical with Duchenne dystrophy. The clinical manifestations of 2 sisters in another family were less severe than in their brother with Duchenne dystrophy. The clinical differences among these 3 cases are well explained by the Lyon hypothesis. Others cases (3) were compatible with childhood muscular dystrophy of autosomal recessive inheritance.