Does Gastrin (Pentagastrin) Act Directly on the Parietal Cell in the Isolated Whole Stomach of the Mouse?

Abstract

Acid secretory effect of pentagastrin and compound 48/80 [p-methoxyphenethyl methylamine-formaldehyde product] was studied in the isolated whole stomach of the mouse. Acid secretory response to compound 48/80 was inhibited by cimetidine, indicating histamine involvement in this reaction. Acid secretion stimulated by pentagastrin was not diminished after pretreatment with compound 48/80; apparently gastrin releases non-mast cell histamine. Secretory response to pentagastrin was reduced in Ca2+-free serosal media but not to histamine and compound 48/80. A possible pathway of gastrin will be discussed.