Acute nephrotoxicity following cis-dichlorodiammine-platinum
- 1 May 1982
- Vol. 49 (9), 1784-1788
- https://doi.org/10.1002/1097-0142(19820501)49:9<1784::aid-cncr2820490909>3.0.co;2-6
Abstract
The effects of a single dose of cis-diamminedichloroplatinum (DDP) on the kidney function were investigated in 14 patients with disseminated malignancy and normal renal function. A single dose of DDP (30–50 mg/m2) caused severe proximal tubular dysfunction with increased urinary losses of calcium, magnesium, and amino acids. Phosphate excretion was not affected. DDP can cause proximal tubular dysfunction and close attention must be paid to serum calcium and magnesium levels.This publication has 18 references indexed in Scilit:
- Hypomagnesemia and Renal Magnesium Wasting in Patients Receiving CisplatinAnnals of Internal Medicine, 1979
- The Role of cis-Platinum in Solid-Tumor TherapyNew England Journal of Medicine, 1979
- Long term effect of Cis-Diamminedichloride platinum (CDDP) on renal function and structure in manCancer, 1978
- Cis-Diamminedichloroplatinum, Vinblastine, and Bleomycin Combination Chemotherapy in Disseminated Testicular CancerAnnals of Internal Medicine, 1977
- Cis-diamminedichloroplatinum (II)Annals of Internal Medicine, 1977
- Improvement of Cis-dichlorodiammineplatinum (NSC 119875): Therapeutic index in an animal modelCancer, 1977
- High dose Cis-platinum diammine dichloride.Amelioration of renal toxicity by mannitol diuresisCancer, 1977
- Inhibition of Transport ReactionsPublished by Elsevier ,1972
- Antileukaemic and Nephrotoxic Properties of Platinum CompoundsNature, 1971
- CHARACTERISTICS OF ACIDIC AMINO ACID TRANSPORT IN MAMMALIAN KIDNEYCanadian Journal of Biochemistry and Physiology, 1963