Enhancement by Retinyl Acetate of Hormone-Induced Mammary Tumorigenesis in Female GR/A Mice23
- 1 October 1981
- journal article
- research article
- Published by Oxford University Press (OUP) in JNCI Journal of the National Cancer Institute
- Vol. 67 (4), 935-938
- https://doi.org/10.1093/jnci/67.4.935
Abstract
Feeding of retinyl acetate (82 mg/kg ration) for 13–16 weeks to estrone- and progesterone-treated nulliparous and multiparous inbred GR/A mice resulted in a substantial increase in the incidence of mammary carcinomas. Mammary carcinoma incidence in nulliparous control and retinoid-fed mice in experiment #1 was 22/65 (34%) and 37/65 (57%) (PP< 0.05), respectively. Mammary carcinoma incidence in multiparous control and retinoid-fed mice in experiment #1 was 13/30 (43%) and 23/30 (77%) (P<0.05), respectively; in experiment #2, 19/19 (100%) and 19/19 (100%), respectively. The purported chemopreventive activities of retinyl acetate in murine mammary tumorigenesis were not demonstrated in this study; indeed, the vitamin A analog appeared to enhance this oncogenic process in the steroid hormone-treated GR mouse mammary cancer model.Keywords
This publication has 12 references indexed in Scilit:
- Inhibition of mammary tumorigenesis in GR mice with 2-bromo-α-ergocryptineInternational Journal of Cancer, 1979
- EFFECT OF THE DURATION OF RETINYL ACETATE FEEDING ON INHIBITION OF 1-METHYL-1-NITROSOUREA-INDUCED MAMMARY CARCINOGENESIS IN THE RAT1979
- N-(4-HYDROXYPHENYL)RETINAMIDE - NEW RETINOID FOR PREVENTION OF BREAST-CANCER IN THE RAT1979
- DNA Labeling Index and Structure of the Rat Mammary Gland as Determinants of Its Susceptibility to Carcinogenesis2JNCI Journal of the National Cancer Institute, 1978
- Plasminogen activator in chick fibroblasts: Induction of synthesis by retinoic acid; synergism with viral transformation and phorbol esterCell, 1978
- INHIBITORY EFFECT OF 13-CIS-RETINOIC ACID ON URINARY-BLADDER CARCINOGENESIS INDUCED IN C57BL-6 MICE BY N-BUTYL-N-(4-HYDROXYBUTYL)-NITROSAMINE1978
- Suppression of Mammary Tumorigenesis in C3H/He Mice by Ovariectomy or Treatment With 2-Bromo- α -ergocryptine: A Comparison 2JNCI Journal of the National Cancer Institute, 1977
- 13- cis -Retinoic Acid: Inhibition of Bladder Carcinogenesis in the RatScience, 1977
- PROLACTIN AND MURINE MAMMARY TUMORIGENESIS - REVIEW1977
- INHIBITION OF MAMMARY-CANCER BY RETINYL METHYL-ETHER1977