THE SOLUBILITY OF ACETYLSULFAPYRIDINE AND ACETYLSULFATHIAZOLE IN THE URINE

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Abstract
To prevent the precipitation of acetylsulfapyridine and acetylsulfathiazole crystals in the urine, the fluid output must be sufficient to hold all of these compounds in soln. The solubility of both acetylsulfapyridine and acetylsulfathiazole is greater in an alkaline urine than in an acid urine, so that enough base should always be taken with these drugs to keep the pH of the urine alkaline. Urea seems to have some importance in the solubility of acetylsulfapyridine in the urine.