IMMUNOHISTOLOGIC STUDIES ON ANTIGEN-ANTIBODY REACTIONS IN THE AVASCULAR CORNEA
Open Access
- 1 May 1962
- journal article
- research article
- Published by Rockefeller University Press in The Journal of Experimental Medicine
- Vol. 115 (5), 919-928
- https://doi.org/10.1084/jem.115.5.919
Abstract
The injection of antigen into the center of the avascular cornea of homologously sensitized animals induced a ring of opacification between the center of the cornea and the limbus. This ring of opacification was composed of a line of deeply eosinophilic amorphous material in a matrix of swollen collagen fibers, palisaded by polymorphonuclear leucocytes. By use of fluor-tagged antigen, it was shown that the line of damage in the cornea coincided with the precipitation of antigen presumably by antibody entering the cornea from the limbal vessels. With the passage of time, the antigen-antibody precipitates were removed, at least in part by phagocytosis, and the ring of opacification was replaced by ingrowing blood vessels surrounded by plasma cells.This publication has 6 references indexed in Scilit:
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