Ion transport by lasalocid A across red‐blood‐cell membranes

Abstract
Na+ and K+ fluxes mediated by lasalocid A across erythrocyte membranes have been determined from 23Na-NMR peak areas and chemical shifts, respectively. In similar experiments, Cl- transport has been monitored by NMR signal intensities. Taking into account the external pH variations, the results are readily explainable in terms of charge-balance conservation. The effect of disodium 4,4''-diisothiocyanostilbene-2,2''-disulfonate, an anion-exchange inhibitor, has also been studied.