A New Model of Skin Injury.

Abstract

Topical application of xylene on skin sites subjected to either epinephrine, norepinephrine or vasopressin vasoconstriction modifies for a number of days their reactivity to a variety of agents. The sites become refractory to the inflammatory action of xylene, their reactivity to local injections of histamine or serotonin is greatly diminished, and 48/80 is without effect. The changed cutaneous reactivity is though to result from the initial activation of the axon reflex and its subsequent suppression by xylene combined with extensive depletion of skin vasodilating amines.