BIOLOGICAL PROPERTIES OF CELL WALL MUCOPEPTIDE OF HEMOLYTIC STREPTOCOCCI
Open Access
- 1 July 1969
- journal article
- Published by Rockefeller University Press in The Journal of Experimental Medicine
- Vol. 130 (1), 31-47
- https://doi.org/10.1084/jem.130.1.31
Abstract
Several of the toxic properties of streptococcal mucopeptide have been studied in detail. Intravenous injection of as little as 1 µg of mucopeptide, solubilized by ultrasonic treatment, elicits a reproducible febrile response. Rabbits which are made tolerant to Escherichia coli endotoxin are only partially tolerant to the subsequent injection of streptococcal mucopeptide. Soluble mucopeptide was successfully employed to prepare and provoke the localized Shwartzman reaction.Keywords
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