Tumor Formation With Transplants of Spleen or Liver From Mice With Virus-Induced Leukemia23

Abstract

Solid tumors were established from grafts of both the spleen and liver of a strain DBA/2 mouse with a virus-induced leukemia. The tumors, composed of the large, undifferentiated mononuclear cells characteristic of this virus leukemia, were serially transplantable to 100 percent of DBA/2 mice. Thus far, after 21 serial generations the tumors contain appreciable amounts of virus. The course of the disease was more rapid in mice implanted with local tumors than in those inoculated intraperitoneally with the virus. Tumor-bearing mice succumbed with generalized leukemia within approximately 35 days in contrast to those injected with virus, which had an average survival time of about 70 days. However, when transplantation to the randombred Swiss mice was attempted, tumors rarely developed.