Delivery of a Quaternary Pyridinium Salt Across the Blood-Brain Barrier by Its Dihydropyridine Derivative
- 10 October 1975
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 190 (4210), 155-156
- https://doi.org/10.1126/science.1166305
Abstract
A dihydropyridine-pyridine type redox system was successfully applied for delivering a quaternary pyridinium salt, N-methylpyridinium-2-aldoxime chloride (2-PAM), through the blood-brain barrier. The dihydropyridine derivative of 2-PAM was quickly oxidized to 2-PAM after crossing the blood-brain barrier. As a result of this approach, the brain cholinesterase blocked by organophosphates could be reactivated. The new method should be useful in delivering numerous drugs which are otherwise inaccessible to the brain because of their polar ionic character.This publication has 8 references indexed in Scilit:
- Soman and Sarin: Clinical Manifestations and Treatment of Accident of Accidental Poisoning by OrganophosphatesClinical Toxicology, 1974
- The influence of obidoxime on acetylcholinesterase activity in different parts of the mouse brain following isopropylmethyl phosphonofluoridate intoxicationEuropean Journal of Pharmacology, 1972
- Chemistry of dihydropyridinesChemical Reviews, 1972
- Prevention and Management of Organophosphate PoisoningPublished by American Medical Association (AMA) ,1971
- Synthesis of aldoxime analogs of arecoline as reactivators of organophosphorus inhibited cholinesteraseJournal of Pharmaceutical Sciences, 1967
- Technical Requirements and Identification of Pralidoxime Chloride and its Determination in Biological MaterialJournal of Pharmaceutical Sciences, 1965
- A new and rapid colorimetric determination of acetylcholinesterase activityBiochemical Pharmacology, 1961
- Designing of a new drug with antidotal properties against the nerve gas sarinBiochimica et Biophysica Acta, 1958