The Relationship of Dietary Factors to the Toxicity of Alloxan
- 1 December 1949
- journal article
- research article
- Published by Elsevier in Journal of Nutrition
- Vol. 39 (4), 529-541
- https://doi.org/10.1093/jn/39.4.529
Abstract
The influence of dietary factors on the sensitivity of rats to alloxan has been investigated. The diet was varied with respect to its content of protein and fat, and supplements of methionine, choline, tocopherol, and yeast were given. The toxicity of alloxan, as measured by the number of rats which survived for 7 days after its injection, was decreased appreciably only when diets very low in fat were fed. There was a slight advantage shown by cocoanut oil over lard or hydrogenated cottonseed oil in the high fat diets. The hemolysis which occurred when alloxan was administered to tocopherol-deficient rats caused a high death rate during the first two days after the injection. Tocopherol and, in an apparently somewhat similar fashion, yeast, reduced the early mortality but had no effect after this initial period. Diabetes developed in most of the animals regardless of the nature of the diet. Considering those animals as diabetic whose blood sugar, 48 hours after injection with alloxan, was above 200 mg per 100 ml, the incidence of diabetes was slightly, but significantly, lower with diets low in fat or containing cocoanut oil than with those containing lard or hydrogenated cottonseed oil. There was no evidence of any benefit from any other of the variations in diet studied. Even tocopherol, in spite of its very specific effect in preventing hemolysis following the injection of alloxan, gave no protection against the diabetogenic effect of alloxan.Keywords
This publication has 12 references indexed in Scilit:
- TOCOPHEROL AND HEMOLYSIS IN VIVO AND IN VITROAnnals of the New York Academy of Sciences, 1949
- Effect of Dietary Factors on Early Mortality and Hemoglobinuria in Rats Following Administration of AlloxanScience, 1948
- ALLOXAN DIABETESPhysiological Reviews, 1948
- Experimental Diabetes and DietScience, 1947
- A PHOTOMETRIC ADAPTATION OF THE SOMOGYI METHOD FOR THE DETERMINATION OF GLUCOSEJournal of Biological Chemistry, 1944
- Experimental Hepatic InjuryAmerican Journal of Clinical Pathology, 1944
- Über einen tödlichen, ernährungsbedingten Leberschaden und das Vorkommen von LeberschutzstoffenHoppe-Seyler´s Zeitschrift Für Physiologische Chemie, 1944
- ANTIOXIDANT ACTIVITY IN SOURCES OF THE B VITAMINSPublished by Elsevier ,1943
- A REAGENT FOR THE COPPER-IODOMETRIC DETERMINATION OF VERY SMALL AMOUNTS OF SUGARJournal of Biological Chemistry, 1937
- Das Alloxan als Oxydationsmittel für Thiolgruppen, als Kapillargift und als KrampfgiftNaunyn-Schmiedebergs Archiv für experimentelle Pathologie und Pharmakologie, 1930