Inhibition of gastric secretion by atropine in conscious rats
- 1 September 1971
- journal article
- Published by Wiley in The Journal of Physiology
- Vol. 217 (3), 723-735
- https://doi.org/10.1113/jphysiol.1971.sp009596
Abstract
1. The effect of atropine on acid and pepsin secretion, stimulated by feeding, vagus excitation or infusions of gastrin, histamine and methacholine, was studied in conscious rats provided with a Pavlov or a Heidenhain pouch.2. The acid and pepsin secretion in response to food was substantially suppressed by atropine in the Pavlov pouch.3. The strong stimulatory effect of 2-deoxy-D-glucose on acid and pepsin secretion in the Pavlov pouch was almost abolished by atropine.4. A plateau secretion of acid obtained by infusion of submaximal doses of hog gastrin II, was significantly inhibited by atropine in the Pavlov and the Heidenhain pouch.5. Methacholine-induced acid and pepsin secretion in the denervated Heidenhain pouch was nearly completely inhibited by atropine.6. A plateau secretion of acid evoked by infusing histamine in a near maximal dosage was inhibited by atropine to the same extent as the gastrin-induced secretion in the Pavlov pouch.7. The mode of action of atropine as a gastric secretory inhibitor is discussed.Keywords
This publication has 20 references indexed in Scilit:
- Evidence of gastrin-like activity in the rat's antrumCellular and Molecular Life Sciences, 1970
- The role of the antrum and the vagus nerve in the formation of gastric mucosal histamineThe Journal of Physiology, 1969
- Quantitative estimation of 17α-hydroxypregn-4-ene-3,20-dione (17αOH-progesterone) in adrenal venous blood and adrenal glands1968
- MODE OF ACTION OF A GASTRIC‐SECRETION ANTAGONISTBritish Journal of Pharmacology and Chemotherapy, 1968
- Effect of graded doses of pentagastrin, histamine and 2-deoxy-D-glucose on gastric secretion and motility in conscious rats.1968
- Vagal gastric secretory stimulation by 2-deoxy-d-glucoseAmerican Journal of Physiology-Legacy Content, 1965
- Observations on the inhibition of histamine formationThe Journal of Physiology, 1963
- The preparation and properties of gastrinThe Journal of Physiology, 1961
- Preparation of chronic denervated gastric pouches in the ratAmerican Journal of Physiology-Legacy Content, 1959
- Comparison of the Effects of Methantheline Bromide (Banthine) and Atropine on the Secretory Responses of Vagally Innervated and Vagally Denervated Gastric PouchesGastroenterology, 1951