Opsonin System of the Group B Streptococcus
- 1 December 1974
- journal article
- research article
- Published by American Society for Microbiology in Infection and Immunity
- Vol. 10 (6), 1315-1320
- https://doi.org/10.1128/iai.10.6.1315-1320.1974
Abstract
The opsonization by polymorphonuclear leukocytes of group B streptococcal serotypes associated with neonatal sepsis and delayed meningitis was studied. A specific BIa opsonizing antibody (not related to the antipolysaccharide typing antibody) was present in only 10% of the population tested. Serotype BIa was not opsonized in the absence of this specific antibody. BIa antibody specificity was demonstrated by macroagglutination and absorption with BIa streptococci and extracts, but not by gel diffusion. The binding of complement by the BIa opsonin increased the mean phagocytic activity by 60%; complement was manifested via the classic and/or alternate C3-related pathway, but seldom by both concurrently. Serotypes BIb, BIc, BII, and BIII were naturally and nonspecifically opsonized in 95% of the human and baboon sera or plasma tested. Although similar levels of opsonization were present in hyperimmune rabbit sera, heat inactivation and homologous bacterial absorption did not reduce the level of phagocytic activity in the rabbit, human, or primate groups studied. These immunological studies confirmed previous findings that serotype BIa presents a serious hazard for neonatal sepsis, with a nearly 100% mortality. Exclusive isolation of BIII in delayed meningitis suggests that ingestion and subsequent killing by polymorphonuclear leukocytes of type III may differ from the other serotypes.Keywords
This publication has 21 references indexed in Scilit:
- Cellular and humoral immune response to group B streptococciThe Journal of Pediatrics, 1973
- Transmission of group B streptococci among parturient women and their neonatesThe Journal of Pediatrics, 1973
- Opsonins: Their function, identity, and clinical significanceThe Journal of Pediatrics, 1973
- Suppurative meningitis due to streptococci of lancefield group B: A study of 33 infantsThe Journal of Pediatrics, 1973
- Group B streptococci: The new challenge in neonatal infectionsThe Journal of Pediatrics, 1973
- Group B streptococcal neonatal and infant infectionsThe Journal of Pediatrics, 1973
- Leukocyte Function and the Development of Opsonic and Complement Activity in the NeonateArchives of Pediatrics & Adolescent Medicine, 1971
- ELECTRON MICROSCOPIC STUDIES ON STREPTOCOCCIThe Journal of Experimental Medicine, 1969
- Impaired Opsonic Activity but Normal Phagocytosis in Low-Birth-Weight InfantsNew England Journal of Medicine, 1969
- THE ENHANCEMENT OF BACTERIAL PHAGOCYTOSIS BY SERUMThe Journal of Experimental Medicine, 1969