A functional assessment of macrophages from osteopetrotic mice

Abstract

Macrophages from osteopetrotic mice caused less bone resorption than normal sib macrophages in culture. The bone-resorbing activity lay in the culture supernatant, and reduced activity in cultures of macrophages from osteopetrotic mice correlated with reduced glass spreading and reduced latex phagocytosis. Apparently macrophages from osteopetrotic mice show defective phagocytic recognition of glass, latex and bone. Apparently this defective recognition may reflect the cause of the resorption failure resulting in osteopetrosis.