Studies in detoxication. 74. The metabolism of benzhydrol, benzophenone and p-hydroxybenzophenone
- 1 April 1958
- journal article
- research article
- Published by Portland Press Ltd. in Biochemical Journal
- Vol. 68 (4), 584-586
- https://doi.org/10.1042/bj0680584
Abstract
Benzhydrol when given to rabbits is excreted as an acid labile glucuronide. The metabolite was isolated and characterized. No reduction of the keto group takes place when p-hydroxybenzophenone is administered, and the compound is excreted as a stable glucuronic acid conjugate which was isolated. Benzophenone is reduced in the rabbit to benzhydrol. The labile glucuronic acid conjugate of benzhydrol which is excreted was isolated, and production of phenolic derivatives by ring oxidation was not detected. No ethereal sulfate conjugation was detected.Keywords
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