Human immunodeficiency virus infection of human brain capillary endothelial cells occurs via a CD4/galactosylceramide-independent mechanism.
- 15 November 1993
- journal article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 90 (22), 10474-10478
- https://doi.org/10.1073/pnas.90.22.10474
Abstract
Neuropathologic studies of AIDS patients have shown that brain capillary endothelial cells are a cellular target for human immunodeficiency virus (HIV) in vivo. We have established in vitro cultures of primary human brain capillary endothelial (HBCE) cells. Using this model system, we have shown a significant HIV infection of HBCE cells that is productive yet noncytopathic. The infection is mediated by a cellular interaction with gp120 that does not involve CD4 or galactosylceramide. HIV infection of HBCE cells may contribute to AIDS-associated neuropathology by disturbing the physiology of the endothelium and directly or indirectly facilitating dissemination of virus to the central nervous system.Keywords
This publication has 40 references indexed in Scilit:
- Interaction of Human Immunodeficiency Virus with Human Macrovascular Endothelial CellsIn VitroAIDS Research and Human Retroviruses, 1992
- Human immunodeficiency virus infection in microglia: Correlation between cells infected in the brain and cells cultured from infectious brain tissueAnnals of Neurology, 1992
- Specific Tropism of HIV-1 for Microglial Cells in Primary Human Brain CulturesScience, 1990
- Infection of Brain Cells by Diverse Human Immunodeficiency Virus Isolates: Role of CD4 as ReceptorJournal of General Virology, 1989
- Neuronal cell killing by the envelope protein of HIV and its prevention by vasoactive intestinal peptideNature, 1988
- The Brain in AIDS: Central Nervous System HIV-1 Infection and AIDS Dementia ComplexScience, 1988
- Shedding and Interspecies Type Sero-reactivity of the Envelope Glycopolypeptide gp120 of the Human Immunodeficiency VirusJournal of General Virology, 1986
- Detection of AIDS Virus in Macrophages in Brain Tissue from AIDS Patients with EncephalopathyScience, 1986
- Isolation of HTLV-III from Cerebrospinal Fluid and Neural Tissues of Patients with Neurologic Syndromes Related to the Acquired Immunodeficiency SyndromeNew England Journal of Medicine, 1985
- Recent advances in understanding brain capillary functionAnnals of Neurology, 1983