Age-related Changes in Mitogen-induced Lymphocyte Function from Birth to Old Age
Open Access
- 1 August 1983
- journal article
- research article
- Published by Oxford University Press (OUP) in American Journal of Clinical Pathology
- Vol. 80 (2), 159-163
- https://doi.org/10.1093/ajcp/80.2.159
Abstract
This study examines the relationship between age and mitogeninduced lymphocyte blastogenesis. Lymphocytes were stimulated with PHA; Concanavalin A (Con A), and PWM in 156 normal, healthy subjects ranging in age from birth to 75 years. The findings indicate a gradual but significant decrease in PHA– and Con A-induced blastogenesis with increasing age. The decrease in Con A and PHA induced in vitro lymphocyte function begins in early childhood and young adulthood, respectively, and continues throughout the age range studied. In addition, there appears to be a decreased range of lymphocyte functional capacity among the 50–75-year-old subjects. The clinical and laboratory implications of these observations are discussed.Keywords
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