Functional 2:1 A-V Block within the His-Purkinje System

Abstract

In eight subjects in whom the effective refractory period of the His-Purkinje system was determined to be longer than that of the A-V node or atrium, abrupt acceleration of the atrial rate resulted in either 2:1 block within the His-Purkinje system or 1:1 A-V conduction. The former conduction pattern simulated a type II second-degree A-V block. The occurrence of either 2:1 block within the His-Purkinje system or 1:1 A-V conduction was determined primarily by (1) an effective refractory period of the His-Purkinje system which exceeded that of the A-V node, (2) the coupling interval of the first atrial capture beat and its effect or lack thereof on the refractory period of His-Purkinje system as it relates to changes in ventricular cycle length, and (3) the relative speed of A-V nodal conduction time. The distinction between this functional 2:1 block within the His-Purkinje system and a true type II second-degree block is discussed from both the clinical and electrophysiologic points of view. Functional 2:1 block within the His-Purkinje can also result when sudden acceleration of atrial rate occurs spontaneously such as in atrial flutter or A-V nodal reentrant atrial tachycardias.