COMPARATIVE ACTIVITIES OF TWO GONADOTROPIN PREPARATIONS FROM THE URINE OF POSTMENOPAUSAL WOMEN*

Abstract

Two preparation of human gonadotropin (HPG) from postmenopausal urine[long dash]HMG-J5 and Pergonal[long dash]extracted and purified by a chromato-graphic method employing zeolite and Permutit as the adsorbent material, respectively, were tested in 4 bio-assay systems. It was found that the activity contained in 1 mg. of HMG-J5 was somewhat" greater than that contained in 1 mg. of Pergonal. Seven assays were performed; the mean relative potency of Pergonal in terms of HMG-J5 was 0.68. The biologic activities of the 2 preparations studied were similar as judged by Gaddum''s index of discrimination, which did not differ significantly from unity for all combinations of assays.