THE EFFECTS OF CHORIONIC GONADOTROPIN IN KLINEFELTER'S SYNDROME
- 1 December 1959
- journal article
- research article
- Published by The Endocrine Society in Journal of Clinical Endocrinology & Metabolism
- Vol. 19 (12), 1667-1679
- https://doi.org/10.1210/jcem-19-12-1667
Abstract
The effects of large doses of human chorionic gonadotropin administered for long periods of time were studied in a case of Klinefelter ''s syndrome exhibiting the Barr nuclear chromatin body as in the female. There was an evident relationship between the histologic changes in the testes (Leydig cell hyperplasia and signs of active secretion) and the increase in the urinary excretion of 17-KS and estrogens. The mammary tissue showed an increase in the number of ducts with papillary projections lined by multilayered hyperplastic epithelium. Urinary gonadotropin excretion remained unchanged.Keywords
This publication has 15 references indexed in Scilit:
- SEX CHROMATIN PATTERN IN SEMINIFEROUS TUBULE DYSGENESIS AND OTHER TESTICULAR DISORDERS: RELATIONSHIP TO TRUE HERMAPHRODISM AND TO KLINEFELTER'S SYNDROME, WITH A REVIEW OF GONADAL ONTOGENESIS*†Journal of Clinical Endocrinology & Metabolism, 1957
- Advances in the Diagnosis of Altered States of Adrenocortical FunctionNew England Journal of Medicine, 1955
- THE EFFECTS OF GONADOTROPHIC HORMONES IN SURGICALLY CASTRATED WOMENActa Endocrinologica, 1955
- ELASTIC FIBERS IN THE TUNICA PROPRIA OF NORMAL AND PATHOLOGIC HUMAN TESTES*†Journal of Clinical Endocrinology & Metabolism, 1954
- THE EFFECTS OF CHORIONIC GONADOTROPIN IN ADULT MEN: INCREASED ESTROGEN AND 17-KETOSTEROID EXCRETION, GYNECOMASTIA. LEYDIG CELL STIMULATION AND SEMINIFEROUS TUBULE DAMAGE*Journal of Clinical Endocrinology & Metabolism, 1952
- THE DETERMINATION OF URINARY STEROIDS. I. THE PREPARATION OF PIGMENT-FREE EXTRACTS AND A SIMPLIFIED PROCEDURE FOR THE ESTIMATION OF TOTAL 17-KETOSTEROIDSJournal of Clinical Endocrinology & Metabolism, 1952
- TESTICULAR DEFICIENCY: A CLINICAL AND PATHOLOGIC STUDY*†Journal of Clinical Endocrinology & Metabolism, 1950
- Hyalinization of the Seminiferous Tubules Associated with Normal or Failing Leydig-Cell Function. Microscopic Picture in the Testis and Associated Changes in the Breast12Journal of Clinical Endocrinology & Metabolism, 1945
- Experience with a Quantitative Test for Normal or Decreased Amounts of Follicle Stimulating Hormone in the Urine in Endocrinological DiagnosisJournal of Clinical Endocrinology & Metabolism, 1943
- Syndrome Characterized by Gynecomastia, Aspermatogenesis without A-Leydigism, and Increased Excretion of Follicle-Stimulating Hormone1Journal of Clinical Endocrinology & Metabolism, 1942