INDUCTION BY CARBON-TETRACHLORIDE OF A LIPID PEROXIDATION INHIBITOR (LPI) PRESENT IN RAT-LIVER SOLUBLE FRACTION

  • 1 January 1977
    • journal article
    • research article
    • Vol. 17 (2), 265-273
Abstract
Oral administration of an adequate amount of CCl4 to rats resulted in an increase in the ability of the soluble fraction to inhibit microsomal NADPH-dependent lipid peroxidation. Feeding of a fat-free, high carbohydrate diet to rats led to an increase in the ability of the soluble fraction to prevent lipid peroxidation. Partial purification of the soluble factor inhibiting lipid peroxidation (LPI) by means of polyethylene glycol 6000 (PEG) fractionation and hydroxylapatite column chromatography indicated that LPI is not glutathione peroxidase.