How does DNA break during chromosomal translocations?
Open Access
- 15 April 2011
- journal article
- review article
- Published by Oxford University Press (OUP) in Nucleic Acids Research
- Vol. 39 (14), 5813-5825
- https://doi.org/10.1093/nar/gkr223
Abstract
Chromosomal translocations are one of the most common types of genetic rearrangements and are molecular signatures for many types of cancers. They are considered as primary causes for cancers, especially lymphoma and leukemia. Although many translocations have been reported in the last four decades, the mechanism by which chromosomes break during a translocation remains largely unknown. In this review, we summarize recent advances made in understanding the molecular mechanism of chromosomal translocations.Keywords
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