Demonstration of liver disease by radiologic methods has been slow in materializing. One of the more significant developments in recent years has been the introduction of portal venography as a means of liver opacification. This study, developed primarily for visualization of the extrahepatic portal tree, was found to provide fairly satisfactory demonstration not only of the intrahepatic portal branches but also to produce, during passage of contrast medium through sinusoids, a diffuse opacification of liver. The advent of photoscintigraphy has more recently brought still another means of delineating liver disease graphically. It is the purpose of the present essay to present our experience with both scintigraphy and portography in the study of the liver and to compare the two methods to some extent. Material and Technics The livers of 60 patients were studied by scintigraphy. Table I shows a breakdown of this material by diagnosis. Fifteen of the patients for whom scintigrams were obtained were also examined by splenic portography. These included 7 with cirrhosis, 6 with carcinoma, and 2 with hepatic abscess. Our experience with splenic portography in the diagnosis of liver disease includes 84 cases (17) with an established diagnosis of liver cirrhosis, separate from this series, and 11 cases (18) of primary and metastatic carcinoma, also distinct from the 6 carcinomas reported. A. Scintihepatography: A technic projecting the scintigram of the liver directly and simultaneously on the x-ray film was employed. This permits immediate and exact orientation of the scintigraphic findings. This type of projection is achieved by coaxial arrangement of three systems—the collimator, the optical system, and the x-ray beam (Fig. 1). The patient is so positioned that the radioactivated organ is within the axial area of the system. Collimation is achieved by a central lead cone of 6 and 5 mm. inner diameters and 32 mm. length. The two outer lead cones are 68 mm. in length. The smaller one has inner diameters of 15 and 8 mm., and the larger one diameters of 25 mm. and 13 mm. The three cones are arranged concentrically (Fig. 2). Out of a total crystal surface area of 492 sq. mm., this geometry leaves a central circle and two concentric rings, together measuring 280 sq. mm., available for exposure to radiation. The collimating system has a geometrical focus at 8 cm. distance from its upper end. The crystal, however, “sees” a cone-shaped space which has a diameter of 20 mm. at 5 cm. from the collimator and 32 mm. at 10 cm. from the collimator. The superficial planes of the scintiscanned organ are depicted more sharply but superimposed upon them are the deeper planes, which are slightly blurred scintigraphically with increasing depth. This blurring effect is attenuated by the inverse-square law and absorption in the liver.