Electrochemical detection of carbidopa using a ferrocene-modified carbon nanotube paste electrode
Open Access
- 1 January 2009
- journal article
- Published by National Library of Serbia in Journal of the Serbian Chemical Society
- Vol. 74 (12), 1443-1453
- https://doi.org/10.2298/jsc0912443y
Abstract
A chemically modified carbon paste electrode (MCPE) containing ferrocene (FC) and carbon nanotubes (CNT) was constructed. The electrochemical behavior and stability of the MCPE were investigated by cyclic voltammetry. The electrocatalytic activity of the MCPE was investigated and it showed good characteristics for the oxidation of carbidopa (CD) in phosphate buffer solution (PBS). A linear concentration range of 5 to 600 ?M CD, with a detection limit of 3.6?0.17 ?M CD, was obtained. The diffusion coefficient of CD and the transfer coefficient (?) were also determined. The MCPE showed good reproducibility, remarkable long-term stability and especially good surface renewability by simple mechanical polishing. The results showed that this electrode could be used as an electrochemical sensor for the determination of CD in real samples, such as urine samples.Keywords
This publication has 19 references indexed in Scilit:
- Nanomolar and Selective Determination of Epinephrine in the Presence of Norepinephrine Using Carbon Paste Electrode Modified with Carbon Nanotubes and Novel 2-(4-Oxo-3-phenyl-3,4-dihydro-quinazolinyl)-N′-phenyl-hydrazinecarbothioamideAnalytical Chemistry, 2008
- Flow-batch technique for the simultaneous enzymatic determination of levodopa and carbidopa in pharmaceuticals using PLS and successive projections algorithmTalanta, 2008
- A Novel Electrochemical DNA Biosensor Fabricated with Layer‐by‐Layer Covalent Attachment of Multiwalled Carbon Nanotubes and Gold NanoparticlesElectroanalysis, 2008
- Simultaneous kinetic determination of levodopa and carbidopa by H-point standard addition methodJournal of Pharmaceutical and Biomedical Analysis, 2007
- Chemically Modified Carbon Nanotubes for Use in ElectroanalysisMicrochimica Acta, 2005
- Design and optimization of a chemometrics-assisted spectrophotometric method for the simultaneous determination of levodopa and carbidopa in pharmaceutical productsAnalytica Chimica Acta, 2005
- Nanostructuring electrodes with carbon nanotubes: A review on electrochemistry and applications for sensingElectrochimica Acta, 2005
- Carbon‐Nanotube Based Electrochemical Biosensors: A ReviewElectroanalysis, 2005
- Catalytic growth of carbon nanotubes with large inner diametersJournal of the Serbian Chemical Society, 2005
- Interaction between l-DOPA and 3-O-methyl-l-DOPA for transport in immortalised rat capillary cerebral endothelial cellsNeuropharmacology, 1999