Urate Crystal Induced Inflammation in the Rat: Evidence for the Combined Actions of Kinins, Histamine and Components of Complement
- 1 January 1972
- journal article
- research article
- Published by Taylor & Francis in Immunological Communications
- Vol. 1 (2), 185-198
- https://doi.org/10.3109/08820137209022934
Abstract
The inflammation produced by subplantar injection of sodium urate micro-crystals in the hindpaw of the rat was used as a model of gouty arthritis. Kinins are probably involved since carboxypeptidase B or soybean trypsin inhibitor partially (35%) blocked the edema. Serotonin does not participate since the edema was not prevented by methysergide or cyproheptadine. Histamine is apparently involved since many antihistaminics also partially (40%) suppressed this edema. Two antihistaminics, promethazine and tri-pelennamine, inhibited (75%) the edema as effectively as colchicine by mechanisms as yet not established. Treatment of rats with a combination of soybean trypsin inhibitor and a specific antihistaminic, triprolidine, inhibited the urate edema by 58-66%, which suggested that still another mediator was involved. Complement depletion of the rats also partially (30%) inhibited the edema. The combination of soybean trypsin inhibitor, triprolidine and complement depletion almost completely (80%) suppressed the edema. In the rat, therefore, urate edema appears to be mediated by the combined actions of kinins, histamine and the components of complement.Keywords
This publication has 17 references indexed in Scilit:
- A PREALBUMIN ACTIVATOR OF PREKALLIKREINThe Journal of Experimental Medicine, 1971
- Crystal-Induced Inflammation of the JointsAnnual Review of Medicine, 1970
- Hageman Factor and Acute Gouty ArthritisArthritis & Rheumatism, 1968
- Suppression of urate crystal‐induced canine joint inflammation by heterologous anti‐polymorphonuclear leukocyte SerumArthritis & Rheumatism, 1968
- COMPLEMENT AS A MEDIATOR OF INFLAMMATIONThe Journal of Experimental Medicine, 1967
- The presence of a kinin in inflammatory synovial effusion from arthritides of varying etiologiesArthritis & Rheumatism, 1967
- CRYSTAL-INDUCED INFLAMMATION IN CANINE JOINTSThe Journal of Experimental Medicine, 1966
- Waterfall Sequence for Intrinsic Blood ClottingScience, 1964
- A Multiple Comparison Procedure for Comparing Several Treatments with a ControlJournal of the American Statistical Association, 1955
- The Antihistaminic Drugs. A Review of the LiteratureJournal of the American Pharmaceutical Association (Scientific ed.), 1948