Face Transplantation: Where Do We Stand?
- 15 April 2004
- journal article
- special topics
- Published by Wolters Kluwer Health in Plastic and Reconstructive Surgery
- Vol. 113 (5), 1429-1433
- https://doi.org/10.1097/01.prs.0000112747.85388.39
Abstract
The recent clinical cases of hand and composite tissue allotransplantation opened a new era in the practice of reconstructive surgery. Some have suggested that face (allo)transplantation could be the next step to benefit patients whose conditions cannot be addressed by conventional techniques of reconstructive surgery using autologous tissues. This article reviews the current status of science regarding the prospect of human face transplantation. The main issues fall into three categories: (1) the surgical challenge of the procedure, specifically regarding vascular viability and functional recovery of the graft; (2) the risks of side effects from life-long immunosuppression necessary to prevent graft rejection; and (3) the ethical debate and the effects of the procedure on the population. Although face transplantation could one day be performed and extend the boundaries of reconstructive surgery, there are currently many obstacles that need to be overcome first.This publication has 19 references indexed in Scilit:
- Extending the boundaries of transplantationBMJ, 2003
- First Successful Replantation of Face and Scalp With Single-Artery Repair: Model for Face and Scalp TransplantationAnnals of Plastic Surgery, 2003
- Composite Tissue Allotransplantation and Reconstructive SurgeryAnnals of Surgery, 2003
- Face transplantation—fantasy or the future?The Lancet, 2002
- Clinical Outcome following Nerve Allograft TransplantationPlastic and Reconstructive Surgery, 2001
- What is happening with hand transplants?The Lancet, 2001
- Peripheral nerve regeneration in human hand transplantationTransplantation Proceedings, 2001
- Human hand allograft: report on first 6 monthsThe Lancet, 1999
- The Effect of the Immunosuppressant FK 506 on Peripheral Nerve Regeneration Following Nerve GraftingJournal of Hand Surgery (European Volume), 1999
- Total Face and Scalp ReplantationPlastic and Reconstructive Surgery, 1998