Seizures and Intraventricular Conduction Defect in Propranolol Poisoning

Abstract

Plasma propranolol levels were elevated in both cases. Both patients experienced generalized seizures and had a transient intraventricular conduction defect on ECG. The literature on intoxication of propranolol and other .beta.-adrenoceptor blocking drugs suggests that the effects of massive propranolol intoxication observed in these patients can be explained on the basis of the pharmacologic properties of propranolol. Therapy consisted of gastric lavage and agents to antagonize the .beta.-adrenoceptor blockade effect. Both patients recovered.