SYNTHESIS AND CHARGE‐TRANSFER PROPERTIES OF TWO ACTH ANALOGUES CONTAINING PENTAMETHYLPHENYLALANINE IN POSITION 9
- 12 January 1975
- journal article
- Published by Wiley in International Journal of Peptide and Protein Research
- Vol. 7 (1), 57-67
- https://doi.org/10.1111/j.1399-3011.1975.tb02414.x
Abstract
In order to investigate the possible role of the Trp residue in ACTH as a change-transfer donor in the activation of ACTH receptors, two ACTH analogues (beta-corticotrophins (I-24) with L-Ser1 and D-Ser1, respectively) containing pentamethylphenylalanine instead of Trp have been synthesized. In these syntheses a new, alkaline-labile, amino-protecting group, the methylsulphonylethyloxycarbonyl group, was employed. The association constants of ACTH (I-24) and (Pmp9)-ACTH (I-24) with the water-soluble acceptor paraquat, were nearly equal.Keywords
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