Effect of Intravenous Soy Bean Phosphatides on Blood Coagulation in Rabbits.

Abstract

Rabbits were given intravenous injections of Inosithin, a commercial preparation of soy bean phosphatides with platelet-like coagulation activity. Small doses had little effect on coagulation, but large doses induced depression of prothrombin, Ac globulin, and anti-hemophilic factor. Fibrinogen was unaffected. Changes produced by the in vivo Inosithin were not duplicated by in vitro mixing in that the latter gave smaller increments of change in the prothrombin complex and failed to affect antihemophilic factor. Blood from animals given large doses of Inosithin had an anticoagulant effect on normal rabbit blood, and had platelet-like activity in the plasma.