A protein particle vaccine containing multiple malaria epitopes
- 1 November 1997
- journal article
- Published by Springer Nature in Nature Biotechnology
- Vol. 15 (12), 1280-1284
- https://doi.org/10.1038/nbt1197-1280
Abstract
Ty virus-like particles consist of a single protein species that can be produced in yeast. Recombinant Ty-VLPs carrying a string of up to 15 defined cytotoxic T lymphocyte (CTL) epitopes from Plasmodium species prime protective CTL responses in mice following a single administration without adjuvant. Effective processing of epitopes from the string was demonstrated in vitro and in vivo and was not affected by flanking sequencesKeywords
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