Highly regioselective reduction of unsymmetrical cyclic carboxylic acid anhydrides to γ-lactones

1 January 1976

journal article
research article
Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Chemical Communications

No. 9,p. 314-315
https://doi.org/10.1039/c39760000314

Abstract

The highly regioselective partial reduction of an unsymmetrical carboxylic acid anhydride to the corresponding γ-lactone with LiAlH₄ can be reversed by hydrogenation of the anhydride in the presence of [RuCl₂(Ph₃P)₃] as catalyst.

Keywords

HIGHLY REGIOSELECTIVE
ANHYDRIDE
UNSYMMETRICAL
CARBOXYLIC
CORRESPONDING
PH3P
REVERSED
RUCL2
PARTIAL

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